A new series of pyridinyl-alkynes as antagonists of the metabotropic glutamate receptor 5 (mGluR5)

Bioorg Med Chem Lett. 2006 Sep 15;16(18):4792-5. doi: 10.1016/j.bmcl.2006.06.079. Epub 2006 Jul 12.

Abstract

Synthesis and some structure-activity relationships for a new series of propargyl ethers as mGluR5 antagonists are reported.

MeSH terms

  • Alkynes / chemical synthesis
  • Alkynes / chemistry*
  • Alkynes / pharmacology*
  • Inhibitory Concentration 50
  • Molecular Structure
  • Pyridines / chemistry*
  • Receptor, Metabotropic Glutamate 5
  • Receptors, Metabotropic Glutamate / antagonists & inhibitors*
  • Receptors, Metabotropic Glutamate / metabolism
  • Structure-Activity Relationship

Substances

  • Alkynes
  • Pyridines
  • Receptor, Metabotropic Glutamate 5
  • Receptors, Metabotropic Glutamate
  • pyridine